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CPI-17 alpha Antibody (N-term)

Rabbit Monoclonal Antibody

  • WB - CPI-17 alpha Antibody (N-term) AJ1196a
    A. Western blot analysis of anti-CPI-17 alpha (N-term) RabMAb (Cat. #AJ1196a), dilution 1:5,000. A: Hela B : Jurkat C: MCF-7 D: A431
  • IHC - CPI-17 alpha Antibody (N-term) AJ1196a
    B. Immunohistochemical analysis of paraffin-embedded human normal aorta using anti-CPI- 17 alpha RabMAb (Cat. #AJ1196a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96A00
Reactivity Human, Rat
Host Rabbit
Clonality Monoclonal
Clone Names E305
Calculated MW 16693 Da
Gene ID 94274
Other Names Protein phosphatase 1 regulatory subunit 14A, 17 kDa PKC-potentiated inhibitory protein of PP1, Protein kinase C-potentiated inhibitor protein of 17 kDa, CPI-17, PPP1R14A, CPI17, PPP1INL
Target/Specificity A synthetic peptide corresponding to residues in the N-term of human CPI-17 aplha was used as immunogen. This antibody may also detect isoform CPI-17 beta.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCPI-17 alpha Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP1R14A
Synonyms CPI17, PPP1INL
Function Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Cellular Location Cytoplasm.
Tissue Location Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.
Research Areas
Citations (0)

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PKC Potentiated Inhibitor Protein-17 (CPI-17) is a 17 kDa protein (1). Expressed in smooth muscles and neuronal cells, CPI-17 is a myosin phosphatase inhibitor protein. Phosphorylation of CPI-17 at Thr38 enhances its inhibitory effect by 100 fold (2). Once phosphorylated, CPI-17 inhibits PP1c and MLCP holoenzyme activity (3).


1. Eto M, Ohmori T, Suzuki M, Furuya K & Morita F (1995). J Biochem 118, 1104-1107
2. Eto M, Senba S, Morita F & Yazawa M (1997). FEBS Lett 410, 356-360
3. Senba S, Eto M & Yazawa M (1999). J Biochem 125, 354-362

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Cat# AJ1196a
(40 western blots)
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