|Calculated MW||25039 Da|
|Other Names||C-reactive protein, C-reactive protein(1-205), CRP, PTX1|
|Target/Specificity||A synthetic peptide corresponding to residues near the N-term of human C-reactive protein was used as immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||C-reactive Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.|
|Tissue Location||Found in plasma.|
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Provided below are standard protocols that you may find useful for product applications.
Human C-reactive protein (CRP) was discovered in serum of patients as a nonantibody precipitin of the C-polysaccharide from pneumococci(1). During acute infection, the amounts of circulating CPR increases 100-1000 fold (2). Serum CRP values are routinely measured to detect or monitor many human diseases and minor elevations of C-reactive protein are predictive of cardiovascular events in patients with coronary heart disease (3). CRP promotes host defense, is an efficient activator of the classical C cascade, and shown to be opsonic (4).The opsonic and C activation activities are responsible for the nonspecific host defense activities providing protection in the preimmune stage of acute infections. Additionally, IL-1 and IL-6 are known to stimulate CRP biosyntesis (5).
1. Tillet, W. S. & Francis, T. (1930) J. Exp. Med. 52, 561-571
2. Kushner, I. (1982) Ann. N. Y. Acad. Sci. 389.39-48
3. Ridker, P. M.; Rifai, N.; Rose, L.; Buring, J. E.; Cook, N. R. : New Eng. J. Med. 347: 1557-1565, 2002
4. Mortensen, R. F., Osmand, A. P., Lint, T. F. & Gewurz, H. (1976) J. Immunol. 117,774-781
5. Kleemann R, Gervois PP, Verschuren L, Staels B, Princen HM, Kooistra T. Blood. 2003 Jan 15;101(2):545-51. Epub 2002 Aug 29.
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