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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CUL4A Antibody   

CUL4A Antibody

Rabbit Monoclonal Antibody

  • WB - CUL4A Antibody AJ1207a
    Western blot analysis on (A) HeLa, (B) A375 and (C) 293T cell lysates using anti-CUL4A RabMAb (Cat. #AJ1207a).
  • IHC - CUL4A Antibody AJ1207a
    Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-CUL4A RabMAb (Cat. #AJ1207a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P13646
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3198
Calculated MW 49588 Da
Gene ID 3860
Other Names Keratin, type I cytoskeletal 13, Cytokeratin-13, CK-13, Keratin-13, K13, KRT13
Target/Specificity A synthetic peptide corresponding to residues in human CUL4A was used as an immunogen.
Dilution WB~~1:5000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCUL4A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT13
Tissue Location Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta
Research Areas
Citations (0)

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Cullin proteins assemble a large number of RING E3 ubiquitin ligases and regulate various physiological processes, including regulating replication and transcription , DNA repair and cell cycle progression (1,3). Two cullin 4 (CUL4) proteins, CUL4A and CUL4B, have been identified (1). Cul4A functions as an E3 ligase and participates in the proteolysis of several regulatory proteins through the ubiquitin-proteasome pathway. Cul4A associates with MDM2 and p53. Depletion of Cul4A leads to an accumulation of p53. Moreover, expression of Cul4A increases the decay-rate of p53 and delays the accumulation of p53 in response to DNA damage (2).


1. Liu J, et al. Mol Cell. 10(6):1511-8, 2002 2. Nag A, et al. Caner Res 64(22) :8152-5, 2004 3. Lee J, et al. Mol Cell 26 :775-80

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Cat# AJ1207a
(40 western blots)
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