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CCNE1 Antibody

Rabbit Monoclonal Antibody

  • WB - CCNE1 Antibody AJ1211a
    A. Western blot analysis on Hela cell lysate using anti-Cyclin E1 RabMAb (Cat. #AJ1211a), dilution 1:2,000.
  • IF - CCNE1 Antibody AJ1211a
    B. Immunofluorescent staining of HeLa cells using anti-Cyclin E1 RabMAb (Cat. #AJ1211a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P24864
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP435E
Calculated MW 47077 Da
Gene ID 898
Other Names G1/S-specific cyclin-E1, CCNE1, CCNE
Target/Specificity A synthetic peptide corresponding to residues in human Cyclin E1 was used as immunogen. This antibody is predicted to detect the splice isoform 2 based on sequence analysis.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCNE1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCNE1
Synonyms CCNE
Function Essential for the control of the cell cycle at the G1/S (start) transition.
Cellular Location Nucleus.
Tissue Location Highly expressed in testis and placenta. Low levels in bronchial epithelial cells
Research Areas
Citations (0)

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Cyclin E1 is a member of the cyclin E family that can associate with and activate cyclin-dependent kinase Cdk2. Expression of cyclin E1 is essential for the control of the cell cycle at the late G1 and early S phase (1). The cyclin E/Cdk2 complex plays an essential and limiting role in the transition between G1 and S phase as well as the initiation of DNA replication (2) Ubiquination by the Cul-3 pathway and by Fbw7 regulates cyclin E1 levels and is critically important in normal cells. Abnormally high levels of cyclin E expression have frequently been observed in human cancers (3). Moreover, high cyclin E1 levels correlate with increased tumor aggression and poor prognosis (4).


1. Greider, C.W., and Blackburn, E.H. (1985). Cell 43, 405-413
2. Ohtsubo, M., A. M. Theodoras, J. Schumacher, J. M. Roberts, and M. Pagano. 1995. Mol. Cell. Biol. 15:2612-2624
3. Greider, C.W. (1996). Annu. Rev. Biochem. 65, 337-365
4. Porter et al. 1997. Nat. Med. 3, pp. 222

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Cat# AJ1211a
(40 western blots)
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