Register or Login
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Cyclin H Antibody   

Cyclin H Antibody

Rabbit Monoclonal IgG

  • WB - Cyclin H Antibody AJ1213a
    Western blot analysis on (A) Jurkat, (B) A431, (C) K562, and (D) HeLa cell lysates using anti-Cyclin H RabMAb (Cat. #AJ1213a).
  • IHC - Cyclin H Antibody AJ1213a
    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Cyclin H RabMAb (Cat. #AJ1213a).
  • IF - Cyclin H Antibody AJ1213a
    Immunofluorescent staining of HeLa cells using anti-Cyclin H RabMAb (Cat. #AJ1213a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51946
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EPR3929
Calculated MW 37643 Da
Gene ID 902
Other Names Cyclin-H, MO15-associated protein, p34, p37, CCNH
Target/Specificity A synthetic peptide corresponding to residues in human Cyclin H was used as an immunogen.
Dilution WB~~1:10000~50000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCyclin H Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Cellular Location Nucleus.
Research Areas
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abgent antibody to, and receive a free "I Love Antibodies" mug.


Cyclin H, a member of the cyclin family, functions as a regulator of CDK kinases (1). It associates primarily with the kinase CDK7 and ring finger protein MAT1 to form the CDK-activating kinase (CAK) complex. CAK binds and activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation (2). Cyclin H is also a substrate of protein kinase 2, a ubiquitously expressed serine/threonine protein kinase required for cell viability and cell cycle progression (3). In addition, the CAK complex is a component of TFIIH and the RNA polymerase II protein complex (2). It participates in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery (1).


1. The NCBI handbook [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotech Info; 2002 Oct. Ch. 17, The RefSeq Project. 2. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 37:D169-D174(2009). 3. Bavi P et al. Hum Pathol. 39(6):885-94, 2008.

Abgent welcomes feedback from its customers.

If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at

Cat# AJ1213a
(40 western blots)
Alternative Products:

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanKoreaLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamOthers
Abgent, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
Santa Cruz Alternative
Terms & Conditions