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Cystatin B AntibodyRabbit Monoclonal IgG
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1215a | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
Cystatin B Antibody - Product info | |
| Application | WB, IHC
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| Primary Accession | P04080 |
| Reactivity | Human, Rat |
| Clone Names | EPR3931 |
| Calculated MW | 11140 Da |
| Gene ID 1476 | |
| Target/Specificity A synthetic peptide corresponding to residues in human Cystatin B was used as an immunogen. | |
| Dilution WB~~1:1000~10000 IHC~~1:100~250 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Cystatin B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Cystatin B Antibody - Protein Information | |
| Name CSTB | |
| Synonyms CST6, STFB | |
| Function This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B | |
| Cellular Location Cytoplasm. Nucleus. | |
Cystatin B Antibody - Related products
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AP6775a: Ku70 Antibody (N-term)
AP6775c: Ku70 Antibody (Center)
RI15763: XRCC6 predesign siRNA
LY10971a: XRCC6 Over-expression Lysate
BP5089b: XRCC6 Antibody (C-term) Blocking Peptide
BP5089c: XRCC6 Antibody (Center) Blocking peptide
BP6775a: Ku70 Antibody (N-term) Blocking Peptide
BP6775c: Ku70 Antibody (Center) Blocking Peptide
AT2136a: G22P1 Antibody (monoclonal) (M01)
Cystatin B Antibody - Application data
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Western blot analysis on (A) U87-MG, (B) JAR, and (C) human bladder cell lysates using anti-Cystatin B RabMAb (Cat. #AJ1215a).
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Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-Cystatin B RabMAb (Cat. #AJ1215a).
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Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Cystatin B RabMAb (Cat. #AJ1215a).
Cystatin B Antibody - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Cystatin B is a member of the cysteine protease inhibitor superfamily, functioning as an intracellular thiol protease inhibitor (1). It plays a role in protecting proteinases from lysosomal leakage (1, 2). The second hairpin loop and the C-terminal end of Cystatin B anchor the inhibitor to target proteinases (3). Cystatin B interacts with and inhibits proteases of the cathepsin family (4). A deficiency in cystatin B is observed in progressive myoclonic epilepsy type 1 (1). This deficiency predisposes neurons to oxidative stress that leads to neuronal death and degeneration (1). In addition, Cystatin B has been linked to amyloid fibril formation in vitro and is overexpressed in hepatocellular carcinoma (5, 6).
REFERENCES
1. Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins U, Baltimore, MD. MIM Number: {601145}: {11/27/2006}: . WWW URL: http://www.ncbi.nlm.nih.gov/omim/ 2. Lehtinen MK et al. J Neurosci. 29(18):5910-5, 2009. 3. Pol E et al. Biochemistry. 38(32):10519-26, 1999. 4. Riccio M et al. Exp Cell Res. 262(2):84-94, 2001. 5. Zerovnik E et al. Biochim Biophys Acta. 1594(1):1-5, 2002. 6. Lee MJ et al. Clin Cancer Res. 14(4):1080-9, 2008.
