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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Cystatin B Antibody   

Cystatin B Antibody

Rabbit Monoclonal IgG

     
  • WB - Cystatin B Antibody AJ1215b
    Western blot analysis on (A) human bladder and (B) U87-MG cell lysates using anti-Cystatin B RabMAb (Cat. #AJ1215b).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P04080
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3930
Calculated MW 11140 Da
Gene ID 1476
Other Names Cystatin-B, CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CSTB, CST6, STFB
Target/Specificity A synthetic peptide corresponding to residues in human Cystatin B was used as an immunogen.
Dilution WB~~1:500~1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCystatin B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CSTB
Synonyms CST6, STFB
Function This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.
Cellular Location Cytoplasm. Nucleus
Research Areas
Citations (0)

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Background

Cystatin B is a member of the cysteine protease inhibitor superfamily, functioning as an intracellular protease inhibitor (1). It plays a role in inhibiting cysteine proteinases and protecting proteinases from lysosomal leakage (1, 2). The second hairpin loop and the C-terminal end of Cystatin B anchor the inhibitor to target proteinases (3). A deficiency in cystatin B is observed in progressive myoclonic epilepsy type 1 (1). This deficiency predisposes neurons to oxidative stress that leads to neuronal death and degeneration (1). In addition, Cystatin B has been linked to amyloid fibril formation in vitro and is overexpressed in hepatocellular carcinoma (4, 5).

References

1. Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD. MIM Number: {601145}: {11/27/2006}: . World Wide Web URL: http://www.ncbi.nlm.nih.gov/omim/ 2. Lehtinen et al. J Neurosci. 29(18):5910-5, 2009. 3. Pol et al. Biochemistry. 38(32):10519-26, 1999. 4. Zerovnik et al. Biochim Biophys Acta. 1594(1):1-5, 2002. 5. Lee et al. Clin Cancer Res. 14(4):1080-9, 2008.

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Discontinued
Cat# AJ1215b
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