|Application ||WB, IHC|
|Calculated MW||49588 Da|
|Other Names||Keratin, type I cytoskeletal 13, Cytokeratin-13, CK-13, Keratin-13, K13, KRT13|
|Target/Specificity||A synthetic peptide corresponding to residues in human CK13 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Cytokeratin-13 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta|
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Provided below are standard protocols that you may find useful for product applications.
Keratins are a family of highly homologous proteins expressed as pairs of acidic and basic forms which make intermediate filaments in epithelial cells. Keratin 13 (CK13) is the major acidic keratin, which together with K4, its basic partner, is expressed in the suprabasal layers of non-cornified stratified epithelia (1). White sponge nevus (WSN) is a rare autosomal dominant disorder of non-cornifying squamous epithelial differentiation that presents clinically as bilateral white, soft, thick plaques of the oral mucosa. In WSN, the restriction of lesions to mucosal epithelia and the suprabasal cell histopathology parallels the tissue-specific expression of keratins 4 and 13 in the differentiating cell layers (2).
1. Waseem A, et al. Gene 215(2):269-79, 1998 2. Richard G, et al. Nat Genet 11(4):453-5, 1995
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