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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Cytokeratin-17 Antibody (C-term)   

Cytokeratin-17 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - Cytokeratin-17 Antibody (C-term) AJ1222a
    A. Western blot analysis on HeLa cell lysate using anti-CK-17 RabMAb (Cat. #AJ1222a), dilution 1:10,000.
  • IHC - Cytokeratin-17 Antibody (C-term) AJ1222a
    B. Immunohistochemical analysis of paraffin-embedded human squamous cervical carcinoma using anti-CK-17 RabMAb (Cat. #AJ1222a).
  • IF - Cytokeratin-17 Antibody (C-term) AJ1222a
    C. Immunofluorescent staining of A431 cells using anti-CK-17 RabMAb (Cat. #AJ1222a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q04695
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR1624Y
Calculated MW 48106 Da
Gene ID 3872
Other Names Keratin, type I cytoskeletal 17, Cytokeratin-17, CK-17, Keratin-17, K17, KRT17
Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human CK-17 was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCytokeratin-17 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT17
Function Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q9QWL7}.
Tissue Location Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).
Research Areas
Citations (0)

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Among the members of the cytokeratin (CK) subfamily of intermediate filament (IF) proteins, CK 17 is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. It has an unusual expression pattern in normal and diseased states and has potential importance in tumor diagnosis. CK 17 synthesis seems to be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells (1). It has been shown that CK 17 regulates cell growth through binding to the adaptor protein 14-3-3sigma. These findings reveal a new and unexpected role for the intermediate filament cytoskeleton in influencing cell growth and size by regulating protein synthesis (2). CK 17 is expressed in the nail bed, hair follicle, sebaceous glands, and other epidermal appendages (3).


1. Troyanovsky SM, et al. Eur J Cell Biol 59(1):127-37, 1992.
2. Kim S, et al. Nature 441(7091):362-5, 2006.
3. Covello SP, et al. Br J Dermatol 139(3):475-80, 1998.

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Cat# AJ1222a
(40 western blots)
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