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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Cytokeratin-18 Antibody   

Cytokeratin-18 Antibody

Rabbit Monoclonal Antibody

  • WB - Cytokeratin-18 Antibody AJ1223a
    A.Western blot analysis on 15 ng recombinant protein using anti-Keratin 18 RabMAb (Cat. #AJ1223a), dilution 1:1000.
  • IHC - Cytokeratin-18 Antibody AJ1223a
    B. Immunohistochemical analysis of paraffin-embedded colon carcinoma using anti-Keratin 18 RabMAb (Cat. #AJ1223a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05783
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names E431-1
Calculated MW 48058 Da
Gene ID 3875
Other Names Keratin, type I cytoskeletal 18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, CK-18, Keratin-18, K18, KRT18, CYK18
Target/Specificity A synthetic peptide corresponding to residues of human Cytokeratin 18 was used as immunogen.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCytokeratin-18 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT18
Synonyms CYK18
Function Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Cellular Location Cytoplasm, perinuclear region. Nucleus, nucleolus
Tissue Location Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Research Areas
Citations (0)

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Keratin polypeptides 8 and 18 (K8/18) are intermediate filament phosphoglycoproteins that are expressed preferentially in glandular epithelia. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells (1-3). Together with actin microfilaments and microtubules, keratin filaments make up the cytoskeletons of vertebrate epithelial cells, forming alpha-helical coiled-coil dimers which associate laterally and end-to-end to form 10-nm diameter filaments (4).


1. Ku, N.O. and M.B. Omary. Identification and mutational analysis of the glycosylation sites of human keratin 18. J Biol Chem. 270: 11820
2. Kulesh, D.A. and R.G. Oshima. Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells. Mol Cell Biol. 8: 1540
3. Marceau, N. and A. Loranger. Cytokeratin expression, fibrillar organization and subtle function in liver cells. Biochem. Cell Biol. 73: 619
4. Fuchs, E. Keratins and the skin. Annu. Rev. Cell. Dev. Biol. 11: 123

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Cat# AJ1223a
(40 western blots)
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