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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Cytokeratin-4 Antibody   

Cytokeratin-4 Antibody

Rabbit Monoclonal Antibody

  • WB - Cytokeratin-4 Antibody AJ1226b
    A. Western blot analysis on A431 cell lysate using anti-Cytokeratin 4 RabMAb (Cat. #AJ1226b).
  • IHC - Cytokeratin-4 Antibody AJ1226b
    B. Immunohistochemical staining of paraffin-embedded cervical carcinoma using anti-Cytokeratin 4 RabMAb (Cat. #AJ1226b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P19013
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1599Y
Calculated MW 57285 Da
Other Names Keratin, type II cytoskeletal 4, Cytokeratin-4, CK-4, Keratin-4, K4, Type-II keratin Kb4, KRT4, CYK4
Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human Cytokeratin 4 was used as an immunogen.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCytokeratin-4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT4
Synonyms CYK4
Tissue Location Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer
Research Areas
Citations (0)

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Keratins are a family of structurally related proteins that form the intermediate filament cytoskeleton in epithelial cells. White sponge nevus (WSN) is a benign autosomal dominant disorder which affects non-cornifying stratified squamous epithelial. Keratins are expressed in pairs by epithelial cells in a tissue and cell specific manner. The major differentiation specific keratins of the buccal mucosa, nasal, esophageal and anogenital epithelia are CK-4 and CK-13. The tissue distribution and nature of the lesions in patients affected by WSN suggested that mutations in CK-4 and/or CK-13 might be responsible for this disorder (1). K4 and K13 form heterodimers in normal epithelial cells. In humans, K4 is present in all layers of the epidermis at 10 weeks and gradually disappears, starting from the basal layers at 15 weeks and becoming totally absent at around 20 weeks. This period corresponds to the early fetal period when melanoblasts derived from the neural crest migrate through the dermis into the basal layer of the epidermis (2).


1. Rugg EL. et al. Nat Genet. 11(4):450-2, 1995
2. Ness SL, et al. J Biol Chem 273(37):23904-11, 1998

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Cat# AJ1226b
(40 western blots)
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