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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Cytokeratin-5 Antibody (C-term)   

Cytokeratin-5 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - Cytokeratin-5 Antibody (C-term) AJ1227c
    A. Western blot analysis on A431 cell lysate using anti-CK-5 RabMAb (Cat. #AJ1227c), dilution1:10,000
  • IHC - Cytokeratin-5 Antibody (C-term) AJ1227c
    B. Immunohistochemical analysis of paraffin-embedded human transitional urinary bladder carcinoma using anti-CK5RabMAb.(Cat. #AJ1227c).
  • IF - Cytokeratin-5 Antibody (C-term) AJ1227c
    C. Immunofluorescent staining of A431 cells using anti-CK-5 RabMAb (Cat. #AJ1227c).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P13647
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1601Y
Calculated MW 62378 Da
Gene ID 3852
Other Names Keratin, type II cytoskeletal 5, 58 kDa cytokeratin, Cytokeratin-5, CK-5, Keratin-5, K5, Type-II keratin Kb5, KRT5
Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human CK-5 was used as an immunogen.
Dilution WB~~1:10000~50000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCytokeratin-5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT5
Research Areas
Citations (0)

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Keratins are a family of structurally related proteins that form the intermediate filament cytoskeleton in epithelial cells. The 58-kD keratin CK-5 is highly similar to other type II keratins and less similar to type I keratins and other intermediate filament proteins. The 58-kD keratin is regulated by retinoids in several tissues and is one of four keratins abundantly expressed in epidermal keratinocytes, where it may be important in maintaining structural integrity of the integument (1). Keratin 5 (CK-5) mRNA and protein are shown to be expressed in normal mammary epithelial cells in culture and are absent from tumor-derived cell lines. This makes CK-5 an important marker in the tumorigenic process, distinguishing normal from tumor cells, and decreased CK-5 expression correlates with tumorigenic progression (2). Dowling-Degos disease (DDD) is an autosomal dominant genodermatosis characterized by progressive and disfiguring reticulate hyperpigmentation of the flexures. Loss of function of CK-5 suggests a crucial role for keratins in the organization of cell adhesion, melanosome uptake, organelle transport, and nuclear anchorage (3).


1. Eckert RL, et al. DNA 7(5):337-45, 1988.
2. Trask DK, et al. Proc Natl Acad Sci 87(6)2319-23, 1990
3. Betz RC, et al. Am J Hum Genet 78(3):510-9, 2006.

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Cat# AJ1227c
(40 western blots)
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