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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Cytokeratin-6 Antibody   

Cytokeratin-6 Antibody

Rabbit Monoclonal Antibody

  • WB - Cytokeratin-6 Antibody AJ1228c
    A. Western blot analysis on A431 cell lysate using anti-CK-6 RabMAb (Cat. #AJ1228c), dilution 1:10,000.
  • IHC - Cytokeratin-6 Antibody AJ1228c
    B. Immunohistochemical analysis of paraffin-embedded human squamous cervical carcinoma using anti-CK-6 RabMAb (Cat. #AJ1228c).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02538
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR1602Y
Calculated MW 60045 Da
Gene ID 3853
Other Names Keratin, type II cytoskeletal 6A, Cytokeratin-6A, CK-6A, Cytokeratin-6D, CK-6D, Keratin-6A, K6A, Type-II keratin Kb6, Hom s 5, KRT6A, K6A, KRT6D
Target/Specificity A synthetic peptide corresponding to residues on the N-terminus of human Cytokeratin 6 was used as an immunogen. This antibody is predicted to detect CK-6a, CK-6b and CK-6c
Dilution WB~~1:10000~50000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCytokeratin-6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT6A
Synonyms K6A, KRT6D
Function Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.
Tissue Location Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath
Research Areas
Citations (0)

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The human type II Cytokeratin 6 (CK6) is expressed in a heterogeneous array of epithelial tissues under normal conditions, but is better known for its strong induction in stratified epithelia that feature an enhanced cell proliferation rate or abnormal differentiation. CK6a is clearly the dominant CK6 isoform in skin tissue samples and cultured epithelial cell lines and that the various isoforms are differentially regulated within and between epithelial tissue types. Our findings have direct implications for an understanding of the regulation and function of CK6 during hyperproliferation in stratified epithelia and the search for disease-causing mutations in CK6 sequences in the human population. keratins show a complex regulation with constitutive and inducible components in several stratified epithelia, including the oral mucosa and skin (1). CK6a show a complex regulation with constitutive and inducible components in several stratified epithelia, including the oral mucosa and skin. Studies demonstrate an essential structural role for CK6 isoforms in the oral mucosa, and implicate filiform papillae as being the major stress bearing structures in dorsal tongue epithelium (2).


1. Takahashi K, et al. J Biol Chem 270(31):18581-92, 1995
2. Wong, P et al. J Cell Biol 150(4):921-8, 2000

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Cat# AJ1228c
(40 western blots)
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