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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Cytokeratin-7 Antibody (C-term)   

Cytokeratin-7 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - Cytokeratin-7 Antibody (C-term) AJ1229b
    A. Western blot analysis on HeLa cell lysate using anti-CK-7 RabMAb (Cat. #AJ1229b).
  • IF - Cytokeratin-7 Antibody (C-term) AJ1229b
    B. Immunofluorescent staining of HeLa cells using anti-CK-7 RabMAb (Cat. #AJ1229b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08729
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1620Y
Calculated MW 51386 Da
Gene ID 3855
Other Names Keratin, type II cytoskeletal 7, Cytokeratin-7, CK-7, Keratin-7, K7, Sarcolectin, Type-II keratin Kb7, KRT7, SCL
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus of human CK-7 was used as an immunogen.
Dilution WB~~1:2000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCytokeratin-7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT7
Synonyms SCL
Function Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).
Cellular Location Cytoplasm.
Tissue Location Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus
Research Areas
Citations (0)

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Cytokeratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. Keratin 7 (CK7) is expressed in a wide range of epithelial structures in humans. The expression pattern in mice is similar to the reported human distribution, with substantial expression observed in lung, bladder, mesothelium, hair follicle, and ductal structures (1). Protein expression levels of CK7 appear significantly higher in chromophobe RCC compared to oncocytoma (p < 0.001). Studies provide further evidence that CK7 and parvalbumin immunostains may be useful in differentiating oncocytoma from chromophobe RCC in problematic cases (2). Also, the pattern of immunohistochemical expression of CK 7 along with CK 20 is commonly used to assess possible primary sites of metastatic carcinomas (3).


1. Smith FJ, et al. Biochem Biophys Res Commun. 297(4):818-27, 2002.
2. Adley BP, et al. Anal Quant Cytol Histol 28(4):228-36, 2006
3. Coons SW, et al. Endocr Pathol 16(3):201-10, 2005.

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Cat# AJ1229b
(40 western blots)
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