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DAP-1 Antibody

Rabbit Monoclonal Antibody

  • WB - DAP-1 Antibody AJ1234a
    A. Western blot analysis on NIH3T3 cell lysate using anti-DAP-1 RabMAb (Cat. #AJ1234a), dilution 1:10,000.
  • IHC - DAP-1 Antibody AJ1234a
    B. Immunohistochemical analysis of paraffin-embedded human stomach carcinoma using anti-DAP-1 RabMAb (Cat. #AJ1234a).
  • IF - DAP-1 Antibody AJ1234a
    C. Immunofluorescent analysis of HeLa cells using anti-DAP-1 RabMAb (Cat. #AJ1234a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51397
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names E59
Calculated MW 11165 Da
Gene ID 1611
Other Names Death-associated protein 1, DAP-1, DAP, DAP1
Target/Specificity A synthetic peptide corresponding to C-terminus of human DAP-1 was used as immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDAP-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DAP
Synonyms DAP1
Function Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.
Research Areas
Citations (0)

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Death associated protein 1 (DAP-1) is a 15-kDa protein that functions as a positive mediator of cell death initiated by interferon (IFN-) gamma (1,2). DAP-1 is proline rich and possesses one SH3 binding motif, as well as several consensus protein kinase phosphorylation sites (1). It is localized to the cytoplasm, but the detailed mechanism of its pro-apoptotic function is unclear. DAP-1 and DAP kinase, a unique, 160-kDa calmodulin-dependent serine/threonine kinase, are both unique candidates for positive mediators of programmed cell death induced by IFN-gamma (3).


1. Deiss, L.P., et al. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev. 9: 15
2. Levy-Strumpf, N. and A. Kimchi. Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions. Oncogene 17: 3331
3. Cohen, O. and A. Kimchi. DAP-kinase: from functional gene cloning to establishment of its role in apoptosis and cancer. Cell Death Differ. 8: 6

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Cat# AJ1234a
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