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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DARPP-32 Antibody (C-term)   

DARPP-32 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - DARPP-32 Antibody (C-term) AJ1237b
    A. Western blot analysis on human brain lysate using anti-DARP-32 (C-term) RabMAb (Cat. #AJ1237b), dilution 1:20,000.
  • IHC - DARPP-32 Antibody (C-term) AJ1237b
    B. Immunohistochemical analysis of paraffin-embedded human gastric adenocarcinoma using anti-DARPP-32 (C-term) RabMAb (Cat. #AJ1237b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UD71
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EP721Y
Calculated MW 22963 Da
Gene ID 84152
Other Names Protein phosphatase 1 regulatory subunit 1B, DARPP-32, Dopamine- and cAMP-regulated neuronal phosphoprotein, PPP1R1B, DARPP32
Target/Specificity A synthetic peptide corresponding to residues in the C-term of human DARPP-32 was used as immunogen.
Dilution WB~~1:500~1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDARPP-32 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP1R1B
Synonyms DARPP32
Function Inhibitor of protein-phosphatase 1.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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The 32kDa dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein (DARPP-32) can either function as a serine/threonine kinase or as a serine/threonine phosphatase depending upon which particular amino acid residue is phosphorylated (1). When phosphorylated by protein kinase A (PKA) at threonine 34, DARPP-32 becomes a potent inhibitor of protein phosphatase-1 (2-3). Alternatively, when phosphorylated at threonine 75 by cyclin-dependent kinase 5(Cdk5), DARPP-32 is converted into an inhibitor of PKA (1). DARPP-32 and truncated DARPP (t-DARPP) are overexpressed in gastric cancers (4).


1. Bibb et al. Nature 402: 669-671, 1999.
2. Greengard, P.; Allen, P. B.; Nairn, A. C. : Neuron 23: 435-447, 1999.
3. Hemmings, H. C., Jr.; Greengard, P.; Tung, H. Y.; Cohen, P. : Nature 310: 503-505, 1984.
4. El-Rifai, W.; Smith, M. F., Jr.; Li, G.; Beckler, A.; Carl, V. S.; Montgomery, E.; Knuutila, S.; Moskaluk, C. A.; Frierson, H. F., Jr.; Powell, S. M. :Cancer Res. 62: 4061-4064, 2002.

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Cat# AJ1237b
(40 western blots)
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