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Desmin Antibody

Rabbit Monoclonal Antibody

  • WB - Desmin Antibody AJ1239a
    A. Western blot analysis on mouse heart tissue using anti-Desmin RabMAb (Cat. #AJ1239a).
  • IHC - Desmin Antibody AJ1239a
    B. Immunohistochemical staining of paraffin-embedded human heart muscle using anti-Desmin RabMAb (Cat. #AJ1239a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P17661
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names Y66
Calculated MW 53536 Da
Gene ID 1674
Other Names Desmin, DES
Target/Specificity A synthetic peptide corresponding to C-terminus of human Desmin was used as immunogen. Predicted to cross-react with rat, bovine and pig, based on sequence homology.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDesmin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DES
Function Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
Cellular Location Cytoplasm. Cell membrane, sarcolemma
Research Areas
Citations (0)

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Desmin are class-III intermediate filaments found in muscle cells, and are expressed during the formation of muscle cells or fibers. Cytoskeletal intermediate filaments (IFs) are constructed from two-chain alpha-helical coiled-coil molecules arranged on an imperfect helical lattice (1,2). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Desmin mutations have been linked to familial cardiac and skeletal myopathy (3,4).


1. Stewart, M. Intermediate filament structure and assembly. Curr. Opin. Cell Biol. 5: 3
2. Li, Z.L., et al. Human desmin-coding gene: complete nucleotide sequence, characterization and regulation of expression during myogenesis and development. Gene 78: 243
3. Li, Z.L. and D. Paulin. High level desmin expression depends on a muscle-specific enhancer. J Biol Chem. 266: 6562
4. Goldfarb, L.G., et al. Missense mutations in desmin associated with familial cardiac and skeletal myopathy. Nat Genet. 19: 402

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Cat# AJ1239a
(40 western blots)
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