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DRD1 Antibody

Rabbit Monoclonal Antibody

  • WB - DRD1 Antibody AJ1245a
    A. Western blot analysis on SH-SY5Y cell lysate using anti- D(1A) dopamine receptor RabMAb (Cat. #AJ1245a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21728
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1560Y
Calculated MW 49293 Da
Gene ID 1812
Other Names D(1A) dopamine receptor, Dopamine D1 receptor, DRD1
Target/Specificity A synthetic peptide corresponding to the C-terminal of human D(1A) dopamine receptor protein was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDRD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DRD1
Function Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Cellular Location Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.
Tissue Location Detected in caudate, nucleus accumbens and in the olfactory tubercle.
Research Areas
Citations (0)

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D(1A) dopamine receptor (DRD1) belongs to the G-protein coupled receptor 1 family and it is one of the five types of dopamine receptors (D1-D5) (1). DRD1 is the most expressed dopamine receptor in central nervous system and it is involved in the regulation of neuronal growth & development, and modulation of dopamine receptor D2-mediated events. G protein coupled DRD1 activates adenylyl cyclase which leads to activation of cyclic AMP dependent protein kinases. Polymorphism of DRD1 gene has been implicated in bipolar I disorder and attention deficit hyperactivity disorder (ADHD) (1,2).


1. Bob AJ et al. Am J Med Genet B Neuropsychiatr Genet. 5:34(1):67-72, 2005.
2. Serverino G et al. Am J Med Genet B Neuropsychiatr Genet. 134(1):37-38.2005.

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Cat# AJ1245a
(40 western blots)
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