|Reactivity||Human, Mouse, Rat|
|Calculated MW||49293 Da|
|Other Names||D(1A) dopamine receptor, Dopamine D1 receptor, DRD1|
|Target/Specificity||A synthetic peptide corresponding to the C-terminal of human D(1A) dopamine receptor protein was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DRD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.|
|Tissue Location||Detected in caudate, nucleus accumbens and in the olfactory tubercle.|
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Provided below are standard protocols that you may find useful for product applications.
D(1A) dopamine receptor (DRD1) belongs to the G-protein coupled receptor 1 family and it is one of the five types of dopamine receptors (D1-D5) (1). DRD1 is the most expressed dopamine receptor in central nervous system and it is involved in the regulation of neuronal growth & development, and modulation of dopamine receptor D2-mediated events. G protein coupled DRD1 activates adenylyl cyclase which leads to activation of cyclic AMP dependent protein kinases. Polymorphism of DRD1 gene has been implicated in bipolar I disorder and attention deficit hyperactivity disorder (ADHD) (1,2).
1. Bob AJ et al. Am J Med Genet B Neuropsychiatr Genet. 5:34(1):67-72, 2005.
2. Serverino G et al. Am J Med Genet B Neuropsychiatr Genet. 134(1):37-38.2005.
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