|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||78055 Da|
|Other Names||Segment polarity protein dishevelled homolog DVL-3, Dishevelled-3, DSH homolog 3, DVL3, KIAA0208|
|Target/Specificity||A synthetic peptide corresponding to residues near the C-terminus of human Dsh-3 was used as an immungen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Dsh-3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the signal transduction pathway mediated by multiple Wnt genes.|
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The human DVL-3 gene encodes a predicted 716 amino acid protein which exhibits 98% amino acid identity with mouse Dsh-3 and 49% with Drosophila Dsh. Dsh-3 was mapped to 3q27. The expression of Dsh-3 mRNA was detected in 30 human cell lines and 2 primary cell cultures. Dsh-3 mRNA was detected in normal human breast tissues and tumors. Statistically, there was no difference in Dsh-3 mRNA level between normal breast tissues and tumors. In human colorectal samples, Dsh-3 was expressed equally in matched normal tissues, polyps and tumors. The data indicates that Dsh-3 is widely expressed in human cells and may have a widespread role in signal transduction (1). Results indicate that the human dishevelled genes constitute a multigene family and that Dsh 3 proteins are highly conserved among metazoans.
1. Bui TD, et al. Biochem Biophys Res Commun 239(2): 510-6, 1997.
2. Semenov MV, et al. Genomics 42(2):302-10, 1997
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