|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||97408 Da|
|Other Names||Dynamin-1, DNM1, DNM|
|Target/Specificity||A synthetic peptide corresponding to residues on the C-terminus of human Dynamin-1 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Dynamin-1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton Note=Microtubule-associated|
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Provided below are standard protocols that you may find useful for product applications.
The dynamin family of GTPases is essential for receptor-mediated endocytosis and synaptic vesicle recycling, and it has recently been shown to play a role in vesicle formation from the trans-Golgi network (1). Dynamin-1 is a GTP-, microtubule-, and phospholipid-binding protein that is expressed primarily in brain and almost exclusively expressed in the central nervous system (2). Dynamin-1 is believed to assemble around the necks of clathrin-coated pits and assist in pinching vesicles from the plasma membrane. This role would make dynamin unique among GTPases in its ability to act as a mechanochemical enzyme (1). Dynamin-1 function is apparently essential for scission of newly formed vesicles from the plasma membrane; it has been proposed that dynamin is a regulator of downstream effectors of scission, rather than being directly responsible for it (3).
1. Sontag JM, et al. J Biol Chem 269(6):4547-54, 1994.
2. Sweitzer SM, et al. Cell 93(6):1021-9, 1998.
3. Marks B, et al. Nature 410(6825):231-5, 2001.
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