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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Dynamin-1 Antibody (C-term)   

Dynamin-1 Antibody (C-term)

Rabbit Monoclonal Antibody

     
  • WB - Dynamin-1 Antibody (C-term) AJ1247b
    A. Western blot analysis on 3T3 cell lysate using anti-Dynamin-1 RabMAb (Cat. #AJ1247b), dilution 1:2000
  • IHC - Dynamin-1 Antibody (C-term) AJ1247b
    B. Immunohistochemical staining of paraffin-embedded human brain tissue using anti-Dynamin-1 RabMAb (Cat. #AJ1247b).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession Q05193
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP801Y
Calculated MW 97408 Da
Gene ID 1759
Other Names Dynamin-1, DNM1, DNM
Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human Dynamin-1 was used as an immunogen.
Dilution WB~~1:500~2000
IHC~~1:100~250
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDynamin-1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DNM1
Synonyms DNM
Function Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton Note=Microtubule-associated
Research Areas
Citations (0)

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Background

The dynamin family of GTPases is essential for receptor-mediated endocytosis and synaptic vesicle recycling, and it has recently been shown to play a role in vesicle formation from the trans-Golgi network (1). Dynamin-1 is a GTP-, microtubule-, and phospholipid-binding protein that is expressed primarily in brain and almost exclusively expressed in the central nervous system (2). Dynamin-1 is believed to assemble around the necks of clathrin-coated pits and assist in pinching vesicles from the plasma membrane. This role would make dynamin unique among GTPases in its ability to act as a mechanochemical enzyme (1). Dynamin-1 function is apparently essential for scission of newly formed vesicles from the plasma membrane; it has been proposed that dynamin is a regulator of downstream effectors of scission, rather than being directly responsible for it (3).

References

1. Sontag JM, et al. J Biol Chem 269(6):4547-54, 1994.
2. Sweitzer SM, et al. Cell 93(6):1021-9, 1998.
3. Marks B, et al. Nature 410(6825):231-5, 2001.

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Discontinued
Cat# AJ1247b
Size:
(40 western blots)
Alternative Products:

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