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E-Cadherin Antibody

Rabbit Monoclonal Antibody

  • WB - E-Cadherin Antibody AJ1249a
    A. Western blot analysis on MCF-7 cell lysate using anti-E-cadherin RabMAb (Cat. #AJ1249a), dilution 1:200,000.
  • IHC - E-Cadherin Antibody AJ1249a
    B. Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-E-cadherin RabMAb (Cat. #AJ1249a).
  • IHC - E-Cadherin Antibody AJ1249a
    C. Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma using anti-E-cadherin RabMAb (Cat. #AJ1249a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P12830
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP700Y
Calculated MW 97456 Da
Gene ID 999
Other Names Cadherin-1, CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin, CD324, E-Cad/CTF1, E-Cad/CTF2, E-Cad/CTF3, CDH1, CDHE, UVO
Target/Specificity A synthetic peptide corresponding to residues in the 5th cadherin domain of human E-cadherin was used.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsE-Cadherin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDH1
Synonyms CDHE, UVO
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
Cellular Location Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma- catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane
Tissue Location Non-neural epithelial tissues.
Research Areas
Citations ( 0 )


E-Cadherin, a member of the cadherin superfamily, is implicated as a key player in different cellular processes including development, morphology, polarity, migration and tissue integrity (1-2). E-cadherin is a glycoprotein with an extracellular domain that interacts with other E-cadherin molecules on adjacent cells, thereby establishing adhesion between epithelial cells. Established as a tumor and metastasis suppressor, E-cadherin expression is frequently down-regulated or extinguished in malignancy which strongly correlates with poor prognosis (3-4). Mutations in E-cadherin are found in gastric, breast, colorectal, thyroid and ovarian cancer (5).


1. Mansouri, A.; Goodfellow, P. N.; Kemler, R. : Cytogenet. Cell Genet. 46: 655, 1987.
2. Vleminckx K, Kemler R. Bioessays. 1999;21:211
3. Nollet, F., G. Berx, and F. van Roy. 1999. Mol. Cell Biol. Res. Comm. 2:77
4. Birchmeier, W., and J. Behrens. 1994. Biochim. Biophys. Acta. 1198:11
5. Thoreson MA, Reynolds AB. Differentiation. 2002 Dec;70(9-10):583-9

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Cat# AJ1249a
(40 western blots)
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