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eIF-5A Antibody (N-term)

Rabbit Monoclonal Antibody

  • WB - eIF-5A Antibody (N-term) AJ1256c
    A. Western blot analysis on Jurkat cell lysates using anti-eIF-5A RabMAb(Cat. #AJ1256c), 1:10,000 dilution.
  • IHC - eIF-5A Antibody (N-term) AJ1256c
    B. Immunohistochemical analysis of paraffin embedded adenocarcinoma of uterus using anti-eIF5ARabMAb (Cat. #AJ1256c)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P63241
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP526Y
Calculated MW 16832 Da
Gene ID 1984
Other Names Eukaryotic translation initiation factor 5A-1, eIF-5A-1, eIF-5A1, Eukaryotic initiation factor 5A isoform 1, eIF-5A, Rev-binding factor, eIF-4D, EIF5A
Target/Specificity A synthetic peptide corresponding to residues near the N-term of human eIF-5A was used as immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionseIF-5A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EIF5A
Function mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
Cellular Location Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions
Tissue Location Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level)
Citations (0)

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The human eukaryotic translation initiation factor 5A (eIF-5A) is an 18 kDa protein (1). eIF-5A precursor [(ec-eIF-5A(lys)] is the only cellular protein known to contain a specific lysine residue which is transformed into the unique amino acid hypusine [N-(4-amino-2-hydroxybutyl)-lysine] by a series of post-translational reactions (2). eIF-5A promotes the formation of the first peptide bond during the initial stage of protein synthesis (3).


1. Park,M.H., Chung,S.I., Cooper,H.L. and Folk,J.E. (1984) J. Biol. Chem., 259, 4563
2. Park,M.H., Cooper,H.L. and Folk,J.E. (1982) J. Biol. Chem., 257, 7219
3. Hershey,J.W.B. (1991) Annu. Rev. Biochem., 60, 717

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Cat# AJ1256c
(40 western blots)
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