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EMSY Antibody

Rabbit Monoclonal Antibody

     
  • WB - EMSY Antibody AJ1258a
    A. Western blot analysis on MCF-7 cell lysate using anti-EMSY RabMAb (Cat. #AJ1258a), dilution 1:1,000.
  • IF - EMSY Antibody AJ1258a
    B. Immunofluorescent staining of MCF-7 cells using anti-EMSY RabMAb (Cat. #AJ1258a).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF
Primary Accession Q7Z589
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names Y474
Calculated MW 141468 Da
Gene ID 56946
Other Names Protein EMSY, EMSY, C11orf30
Target/Specificity A synthetic peptide corresponding to residues near the C-term of human EMSY isoform 1 was used as immunogen.
Dilution WB~~1:2000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEMSY Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EMSY (HGNC:18071)
Synonyms C11orf30
Function Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors.
Cellular Location Nucleus. Note=Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process
Citations (0)

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Background

EMSY is a novel protein whose sequence is found in a chromosomal region known to be involved in breast and ovarian cancer (1). The N-terminus of EMSY binds BRCA2 (exon 3). EMSY is capable of silencing the exon 3 encoded transcrip-tional activation domain of BRCA2. EMSY, just like BRCA2, is located in the nucleus and functions with DNA repair and transcriptional regulation factors (2). EMSY was found to be overactive in 13% of sporadic cases of breast cancer and 17% of ovarian cancers and it was also linked with poor survival, specifically in node-negative breast cancer, suggesting that it may be of prognostic value (1).

References

1. Hughes-Davies et al. Cell 115: 523-535, 2003
2. Pilch et al, Biochem. Cell Biol. 81, pp. 123

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Discontinued
Cat# AJ1258a
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