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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   Endo G Antibody (C-term)   

Endo G Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - Endo G Antibody (C-term) AJ1260a
    A. Western blot analysis on HepG2 cell lysate using anti-EndoG RabMAb (Cat. #AJ1260a), dilution 1:2000.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14249
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1665Y
Calculated MW 32620 Da
Gene ID 2021
Other Names Endonuclease G, mitochondrial, Endo G, 3130-, ENDOG
Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human Endo G was used as an immunogen.
Dilution WB~~1:2000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEndo G Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).
Cellular Location Mitochondrion.
Research Areas
Citations (0)

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Endonuclease G (endoG) is a mitochondrion-specific nuclease that translocates to the nucleus during apoptosis. Once released from mitochondria, endoG cleaves chromatin DNA into nucleosomal fragments independently of caspases. Therefore, endoG represents a caspase-independent apoptotic pathway initiated from the mitochondria (1). Endonuclease G (EndoG) is a nuclear-encoded mitochondrial protein reported to be important for both nuclear DNA fragmentation during apoptosis and mitochondrial DNA replication. Findings indicate that EndoG is essential during early embryogenesis and plays a critical role in normal apoptosis and nuclear DNA fragmentation (2).


1. Li LY, et al. Nature 412(6842):95-9, 2001
2. Zhang J, et al. Proc Natl Acad Sci, 100(26):15782-7, 2003.

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Cat# AJ1260a
(40 western blots)
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