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ENTPD5 Antibody

Rabbit Monoclonal Antibody

  • WB - ENTPD5 Antibody AJ1262a
    Western blot analysis on (A) Fetal liver lysates (B) Hela and (C) LNCaP lysates using anti-ENTPD5 RabMAb (Cat. #AJ1262a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75356
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3738
Calculated MW 47517 Da
Gene ID 957
Other Names Ectonucleoside triphosphate diphosphohydrolase 5, NTPDase 5, CD39 antigen-like 4, ER-UDPase, Guanosine-diphosphatase ENTPD5, GDPase ENTPD5, Nucleoside diphosphatase, Uridine-diphosphatase ENTPD5, UDPase ENTPD5, ENTPD5, CD39L4, PCPH
Target/Specificity A synthetic peptide corresponding to residues in human ENTPD5 was used as an immunogen.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsENTPD5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CD39L4, PCPH
Function Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.
Cellular Location Endoplasmic reticulum. Secreted
Tissue Location Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues
Research Areas
Citations (0)

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The ecto-nucleoside triphosphate diphosphohydrolases (eNTPDases) are a family of enzymes that control extracellular nucleotide levels thereby regulating purinergically controlled physiological processes. Six of the eight known NTPDases are membrane-bound and only ENTD5 and 6 can be released as soluble enzymes (1). ENTPD5 promotes reglycosylation reactions involved in glycoproteins folding and quality control in the endoplasmic reticulum. It also hydrolyzes UDP, GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate (2). ENTPD5 is expressed in adult liver, kidney, prostate, testis and colon (1).


1. Murphy-Piedmonte DM, et al. Proteins and proteomics 1747 :251-259, 2005 2. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 36:D190-D195 (2008)

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Cat# AJ1262a
(40 western blots)
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