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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   EPS15R Antibody   

EPS15R Antibody

Rabbit Monoclonal Antibody

  • WB - EPS15R Antibody AJ1266a
    A. Western blot analysis on Hela cell lysate using anti-EPS15R RabMAb (Cat. #AJ1266a), dilution 1:50,000.
  • IHC - EPS15R Antibody AJ1266a
    B. Immunohistochemical staining of paraffin-embedded human breast carcinoma using anti-EPS15R RabMAb (Cat. #AJ1266a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UBC2
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1147Y
Calculated MW 94255 Da
Gene ID 58513
Other Names Epidermal growth factor receptor substrate 15-like 1, Eps15-related protein, Eps15R, EPS15L1, EPS15R
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus of human EPS15R was used as an immunogen.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEPS15R Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EPS15L1
Synonyms EPS15R
Function Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Cellular Location Cell membrane; Peripheral membrane protein. Nucleus. Membrane, coated pit. Note=Localized to plasma membrane coated pits.
Research Areas
Citations (0)

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EPS15 and EPS15R are substrates of the epidermal growth factor (EGF) receptor kinase that are characterized by the presence of a protein:protein interaction domain, the EH domain, and by their ability to bind to the clathrin adaptor protein complex adaptor protein 2. Evidence suggests that eps15 and eps15R are involved in endocytosis (1). The most striking difference between these two related proteins is that Eps15R is also found in the nucleus, whereas Eps15 is excluded from this compartment at steady state (2). Eps15R plays a key role in clathrin-mediated endocytosis of transmembrane receptors. Using a mutational approach, it has been found that the second ubiquitin-interacting motif (UIM) of Eps15 and Eps15R is essential for their ubiquitination (3).


1. Carbone R, et al. Cancer Res., 57(24):5498-504, 1997.
2. Poupon V, et al. J Biol Chem, 277(11):8941-8, 2002.
3. Klapisz E, et al. J Biol Chem, 277(34):30746-53, 2002.

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Cat# AJ1266a
(40 western blots)
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