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Epsin-1 Antibody

Rabbit Monoclonal Antibody

  • WB - Epsin-1 Antibody AJ1267a
    A. Western blot analysis on (A) SH-SY5Y and (B) HeLa cell lysates using anti-Epsin-1 RabMAb (Cat. #AJ1267a), dilution 1:2000.
  • IF - Epsin-1 Antibody AJ1267a
    B. Immunofluorescent staining of SH-SY5Y cells using anti-Epsin1 RabMAb(Cat. #AJ1267a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y6I3
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3023
Calculated MW 60293 Da
Gene ID 29924
Other Names Epsin-1, EH domain-binding mitotic phosphoprotein, EPS-15-interacting protein 1, EPN1
Target/Specificity A synthetic peptide corresponding to residues in human Epsin-1 was used as an immunogen
Dilution WB~~1:5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEpsin-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EPN1
Function Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Membrane, clathrin-coated pit Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity)
Research Areas
Citations (0)

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Epsin-1 is a cytosolic adaptor protein and interacting partner for the EH domain-containing region of Eps15. It is involved in the regulation of clathrin-mediated endocytosis via its direct interactions with clathrin, the clathrin adaptor AP-2, and Eps15 (1-3). Epsin-1 is a cargo-specific adaptor for influenza virus entry through the clathrin-mediated pathway. In addition to being a clathrin-interacting protiein, Epsin-1 is also an ubiquitin-, and phospholipid-interacting protein (4). It also may function in a signaling pathway connecting the endocytic machinery to the regulation of nuclear function (1).


1. Hyman J, et al. J Cell Biol. 149(3):537-46, 2000
2. Timsit YE, et al. Biochem Biophys Res Commun. 328(2):550-9, 2005
3. Rosenthal JA, et al. J Biol Chem. 274(48):33959-65, 1999
4. Chen C, et al. PNAS 105(33):11790-11795, 2008

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Cat# AJ1267a
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