|Calculated MW||14889 Da|
|Other Names||Fatty acid-binding protein, brain, Brain lipid-binding protein, BLBP, Brain-type fatty acid-binding protein, B-FABP, Fatty acid-binding protein 7, Mammary-derived growth inhibitor related, FABP7, BLBP, FABPB, MRG|
|Target/Specificity||A synthetic peptide corresponding to residues in human FABP7 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FABP7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BLBP, FABPB, MRG|
|Function||B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity).|
|Tissue Location||Expressed in brain and other neural tissues.|
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FABP7 is a member of the large family of hydrophobic ligand-binding proteins (FABPs) (1). FABP proteins are involved in lipid metabolism, including uptake and intracellular trafficking of fatty acids and retinoids. In addition, they play a role in gene regulation, cell signaling, cell growth and differentiation. Several reports have suggested a possible role for the different FABP proteins in cancer biology, linking their levels with either increasing or decreasing the degree of malignancy. Nine FABPs (FABP1-FABP9) have been identified (2). FABP7 is a brain-specific protein that is required for the establishment of the radial glial fiber system in the developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (3). It is expressed at high levels in the developing central nervous system (4). FABP7 has also been found in melanocytic lesions and has shown to regulate proliferation and invasion in melanoma cells in vitro, suggesting that it may play a role in cell proliferation and invasion (2).
1. Anthony, T.E., et al., Genes Dev.19(9):1028-33, 2005 2. Slipicevic, A., et al. BMC Cancer 8:276, 2008 3. The UniProt Consortium. The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195 (2008) 4. Xu L.Z., et al., J Biol Chem. 271(40):24711-9, 1996
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