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Factor XIII Antibody

Rabbit Monoclonal Antibody

  • WB - Factor XIII Antibody AJ1283b
    A. Western blot analysis on (A) human placenta and (B) PMBC and (C) rat platelet cell lysates using anti-Factor XIII A RabMAb (Cat. #AJ1283b), dilution 1:2000.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P00488
Reactivity Human, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP3371
Calculated MW 83267 Da
Gene ID 2162
Other Names Coagulation factor XIII A chain, Coagulation factor XIIIa, Protein-glutamine gamma-glutamyltransferase A chain, Transglutaminase A chain, F13A1, F13A
Target/Specificity A synthetic peptide corresponding to residues in human Factor XIII A was used as an immunogen.
Dilution WB~~1:1000~2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFactor XIII Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name F13A1
Synonyms F13A
Function Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Cellular Location Cytoplasm. Secreted. Note=Secreted into the blood plasma Cytoplasmic in most tissues, but also secreted in the blood plasma
Research Areas
Citations (0)

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Factor XIII (plasma transglutaminase, fibrin stabilizing factor) is a plasma protein that plays an important role in the final stages of blood coagulation and fibrinolysis. It circulates in blood as a tetramer consisting of two ?A? and two ?B? subunits (1, 2). The amino acid sequence of the enzymatically active subunit, Factor XIII A, is unique and does not exhibit internal homology, but its active center is similar to that of the thiol proteases. Factor XIII A is activated by thrombin and calcium ion to a transglutaminase that catalyzes the cross linking of fibrin molecules, forming intermolecular isopeptide bonds, thus stabilizing blood clots (3, 4). In two diseases that share some histological resemblance (Lymphocyte-poor graft-versus-host-reaction and toxic epidermal necrolysis), Factor-XIII A-positive dendrocytes show some morphological changes, probably as a response to altered cytokine environment. Factor-XIII A-positive dendrocytes thus are reported to possibly play a role in the regulation of the connective tissue remodeling that may accompany epidermal destruction (5).


1. Ichinose A, et al. Biochemistry 25(22):6900-6, 1986
2. Ichinose A, et al. Proc Natl Acad Sci U S A. 5(16):5829-33,1988
3. Takahashi N, et al. Proc. Nati. Acad. Sci. USA 83: 8019-8023, 1986
4. U Grundmann, et al. PNAS 83:8024-8028, 1986
5. T. Hermanns-L? et al. Dermatology 198:184-186, 1999

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Cat# AJ1283b
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