|Application ||WB, IHC|
|Calculated MW||21226 Da|
|Other Names||Ferritin heavy chain, Ferritin H subunit, Cell proliferation-inducing gene 15 protein, Ferritin heavy chain, N-terminally processed, FTH1, FTH, FTHL6|
|Target/Specificity||A synthetic peptide corresponding to residues near the C terminus of human Ferritin (heavy chain) was used as an immunogen. This antibody recognizes only the Ferritin heavy chain.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Ferritin Antibody (heavy chain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).|
|Tissue Location||Expressed in the liver.|
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Provided below are standard protocols that you may find useful for product applications.
Ferritin is important in iron homeostasis. It is the main iron-storage protein, composed of two partially homologous subunits, heavy and light chains. Ferritin molecules in cells containing high levels of iron tend to be rich in light chains, and may have a long-term storage function, whereas heavy-rich ferritins are more active in iron metabolism (1-2). Mutations in the ferritin gene cause the hereditary hyperferritinemia-cataract syndrome and neuroferritinopathy, associated with inflammation. Elevated levels of ferritin are reported as characteristic of adult-onset Still's disease and hemophagocytic syndrome, also associated with inflammation (3). Microfilaments and increased levels of exogenous ferritin are excreted directly into the bile by way of a second microfilament-independent, chloroquine-insensitive pathway, supporting a possible physiological mechanism for the release of ferritin from the liver (4).
1. Boyd D, et al. Proc Natl Acad Sci U S A. 81(15):4751-5, 1984
2. Lawson DM, et al. Nature. 349(6309):541-4, 1991
3. Zandman-Goddard G, et al. Autoimmunity Reviews 6(7):457-463, 2007
4. Ramm G A, et al. Hepatology 19(2): 504-513, 2005
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