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Fibrinogen alpha Antibody chain

Rabbit Monoclonal Antibody

  • WB - Fibrinogen alpha Antibody chain AJ1294a
    Western blot analysis on (A) human plasma, (B) fetal liver and (C) HepG2 cell lysates using anti-Fibrinogen alpha chain RabMAb (Cat. #AJ1294a).
  • IHC - Fibrinogen alpha Antibody chain AJ1294a
    Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma using anti-Fibrinogen alpha chain RabMAb (Cat. #AJ1294a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02671
Reactivity Human, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR2919
Calculated MW 94973 Da
Gene ID 2243
Other Names Fibrinogen alpha chain, Fibrinopeptide A, Fibrinogen alpha chain, FGA
Target/Specificity A synthetic peptide corresponding to residues in human Fibrinogen alpha chain was used as an immunogen.
Dilution WB~~1:20000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFibrinogen alpha Antibody chain is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FGA
Function Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3- dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
Cellular Location Secreted.
Tissue Location Plasma.
Research Areas
Citations (0)

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Fibrinogen is a plasma glycoprotein synthesized primarily in the liver (1). It is comprised of two identical molecular halves, each consisting of three non-identical subunit polypeptides designated as A alpha, B beta- and gamma-chains held together by multiple disulfide bonds (2). Fibrinogen acts as the main factor in the formation of a blood clot by polymerization to a fibrin network and by enabling platelets to aggregate (3). The conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Defects in fibrinogen are a cause of congenital afibrinogenemia, a rare autosomal recessive disorder, and amyloidosis type 8, also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis (4).


1. Redman CM, et al. Ann N Y Acad Sci. 936:480-95, 2001 2. Matsuda M, et al. Int J Hematol. 76(1):352-60, 2002 3. Fu Y, et al. Biochemistry 31:11968-11972, 1992 4. The UniProt Consortium, The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-195, (2008)

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Cat# AJ1294a
(40 western blots)
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