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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   Fibrinogen beta Antibody chain   

Fibrinogen beta Antibody chain

Rabbit Monoclonal Antibody

  • WB - Fibrinogen beta Antibody chain AJ1295b
    A. Western blot analysis on (A) human prostate and (B) human plasma lysates using anti-Fibrinogen beta chain RabMAb (Cat. #AJ1295b).
  • IHC - Fibrinogen beta Antibody chain AJ1295b
    B. Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Fibrinogen beta chain RabMAb (Cat. #AJ1295b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02675
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3082
Calculated MW 55928 Da
Gene ID 2244
Other Names Fibrinogen beta chain, Fibrinopeptide B, Fibrinogen beta chain, FGB
Target/Specificity A synthetic peptide corresponding to residues in human Fibrinogen beta chain was used as an immunogen.
Dilution WB~~1:5000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFibrinogen beta Antibody chain is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FGB
Function Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Cellular Location Secreted.
Research Areas
Citations (0)

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Fibrinogen is a heterohexamer and contains 2 sets of 3 non-identical chains (alpha, beta, and gamma). Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of soft clot (1). Various cleavage products of fibrinogen and fibrin, released during coagulation and fibrinolysis, repectively, regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types including fibroblasts, endothelial and smooth muscle cells (2). Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogennemia and thrombotic tendency (3,4). An increase in blood fibrinogen concentration has been identified as an independent risk factor for coronary ateroscelerosis and ischemic heart disease (5,6).


1. Mosesson et al, Ann N Y Acad Sci. 2001; 936:11-30. 2. Herrick et al., Int J Biochem Cell Biol. 1999; 31(7):741-6. 3. Mammen et al., Semin Thromb Hemost 1983; 9:1. 4. Al-Mondhiry et al., Am J Hematol. 1994; 46:343. 5. Handa et al, Atherosclerosis 1989; 77:209. 6. Mannucci et al, Fibrinolysis 1993; 3:51.

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Cat# AJ1295b
(40 western blots)
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