|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||262625 Da|
|Other Names||Fibronectin, FN, Cold-insoluble globulin, CIG, Anastellin, Ugl-Y1, Ugl-Y2, Ugl-Y3, FN1, FN|
|Target/Specificity||A recombinant protein was used as immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Fibronectin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Fibronectins are high molecular weight glycoproteins. Found in plasma or at the cell surface, fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Additionally, binding of fibronectin to collagen, fibrin, heparin, DNA, and actin (1) may trigger key events such as cell migration and repair during the early phases of wound healing (1-3).
1. Yamada,K.M. (1983) Annu. Rev. Biochem., 52, 761-799.
2. Hynes,R.O. and Yamada,K.M. (1982) J. Cell. Biol., 95, 369-377.
3. Skorstengaard,K., Thogersen,H.C., Vibe-Pedersen,K., Petersen,T.E. and Magnusson, S. (1982) Eur. J. Biochem., 128, 605-623
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.