|Application ||WB, IHC|
|Calculated MW||26416 Da|
|Other Names||Fms-related tyrosine kinase 3 ligand, Flt3 ligand, Flt3L, SL cytokine, FLT3LG|
|Target/Specificity||A synthetic peptide corresponding to residues within human Flt3-L was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Flt3-L Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Human Flt3 ligand (Flt3L) stimulates early hematopoiesis by activating a type III tyrosine kinase receptor on primitive bone marrow stem cells. The crystal structure of soluble Flt3L reveals that it is a homodimer of two short chain alpha-helical bundles (1). Flt3 is a hematopoietic growth factor that stimulates cells via specific and structurally related tyrosine kinase receptors on the cell surface (2). This growth factor stimulated the proliferation of hematopoietic progenitor cells isolated from mouse fetal liver or adult mouse bone marrow (3).
1. Savvides SN, et al. Nat Struct Biol. 7(6):486-91, 2000.
2. Lyman SD, et al. Oncogene 11(6):1165-72, 1995.
3. Lyman SD, et al. Blood. 83(10):2795-801, 1994.
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