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FYB Antibody

Rabbit Monoclonal Antibody

  • IHC - FYB Antibody AJ1306b
    B. Immunohistochemical analysis of paraffin-embedded human tonsils using anti-FYB RabMAb (Cat. #AJ1306b)
  • WB - FYB Antibody AJ1306b
    A. Western blot analysis on TF-1 lysate using anti-FYB RabMAb (Cat. #AJ1306b), 1:10,000 dilution.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15117
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP2546Y
Calculated MW 85387 Da
Gene ID 2533
Other Names FYN-binding protein, Adhesion and degranulation promoting adaptor protein, ADAP, FYB-120/130, p120/p130, FYN-T-binding protein, SLAP-130, SLP-76-associated phosphoprotein, FYB, SLAP130
Target/Specificity A synthetic peptide corresponding to residues on the N-terminus of human FYB was used as an immunogen.
Dilution IHC~~1:250~500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFYB Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FYB
Synonyms SLAP130
Function Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.
Cellular Location Cytoplasm. Nucleus. Cell junction {ECO:0000250|UniProtKB:O35601}
Tissue Location Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues
Research Areas
Citations (0)

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FYN-binding protein (FYB) is an adapter protein for Fyn and SLP-76 signaling cascades in T cells. A hematopoietic protein, FYB associates with p59fyn and becomes tyrosine-phosphorylated in response to receptor ligation. FYB has been associated to modulation of IL-2 expression in T cells and platelet activation (3). Fyn (p59Fyn) is a 59 kDa member of the Src family of tyrosine kinases. The carboxy terminus of Fyn shares extensive amino acid sequence homology with Src, but is very different within the amino-terminal 81 amino acid residues. The Fyn protein is synthesized and N-myristoylated on cytosolic polysomes and then rapidly targeted to the plasma membrane, where it is palmitoylated. Fyn's biological functions are diverse and include signaling via the T cell receptor, regulation of brain function and adhesion mediated signaling (2, 3).


1. Renzoni D.A., et al; Biochemistry 35:15646-1565, 1996.
2. Mustelin T, et al., Eur J Immunol. 1992 May;22(5):1173-8.
3. Silva AJ, et al. PNAS USA, 94(14):7493-7498, 1997.

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Cat# AJ1306b
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