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Gab2 Antibody

Rabbit Monoclonal Antibody

  • WB - Gab2 Antibody AJ1309a
    A. Western blot analysis of anti-Gab2 RabMAb (Cat. #AJ1309a), dilution 1:500. A: K562 B: MCF-7
  • IF - Gab2 Antibody AJ1309a
    B. Immunofluorescent staining of PC-12 cells using anti-Gab-2 RabMAb (Cat. #AJ1309a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UQC2
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP369Y
Calculated MW 74458 Da
Gene ID 9846
Other Names GRB2-associated-binding protein 2, GRB2-associated binder 2, Growth factor receptor bound protein 2-associated protein 2, pp100, GAB2, KIAA0571
Target/Specificity A synthetic peptide corresponding to residues in human Gab2 was used as immunogen. This antibody is predicted to detect the splice isoform 2 based on sequence homology.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGab2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GAB2
Synonyms KIAA0571
Function Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Cellular Location Cytoplasm. Cell membrane
Research Areas
Citations (0)

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Gab2 (Grb2-associated binder-2) is an adaptor protein involved in numerous intracellular signaling pathways via its interaction with receptor tyrosine kinases (RTKs), growth factors and cytokines. Gab2 is a substrate of various RTKs, including EGFR, insulin receptor, cytokine receptors as well as B and T cell antigen receptors; Gab2 acts as a docking protein for several SH2-containing proteins (1-3). Upon tyrosine phosphorylation, Gab2 interacts with SHP2 tyrosine phosphatase and GRB2 adaptor protein PI3-kinase, CrkL and SHC (4-5).


1. Zhao, C.; Yu, D.-H.; Shen, R.; Feng, G.-S. : J. Biol. Chem. 274: 19649-19654, 1999.
2. Weiss A, Littman DR: Cell 76:263, 1994
3. Holgado-Madruga, M., Moscatello, D. K., Emlet, D. R., Dieterich, R., and Wong, A. J. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 12419-12424
4. Gu H, Pratt JC, Burakoff SJ, Neel B. Mol Cell. 1998;2:729-740
5. Nishida K, Yoshida Y, Itoh M, et al. Blood. 1999;93:1809-1816

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Cat# AJ1309a
(40 western blots)
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