|Application ||WB, IHC|
|Calculated MW||26152 Da|
|Other Names||Galectin-3, Gal-3, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Galactose-specific lectin 3, Galactoside-binding protein, GALBP, IgE-binding protein, L-31, Laminin-binding protein, Lectin L-29, Mac-2 antigen, LGALS3, MAC2|
|Target/Specificity||A synthetic peptide corresponding to residues in human Galectin-3 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Galectin-3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.|
|Cellular Location||Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface|
|Tissue Location||A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages Expressed in fetal membranes.|
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Provided below are standard protocols that you may find useful for product applications.
Galectins are a family of beta-galactoside-binding animal lectins that are associated with diverse cellular events, including immune response. Glectin-3 has previously been identified in rat, mouse and human tissues and is evolutionarily highly conserved. It is an abundant cell-surface component of inflammatory macrophages and their major non-integrin laminin-binding protein. It is also mainly expressed in colonic epithelial cells. Galectin-3 is a cell surface receptor of the advanced glycosylation end products (AGE), which has involvement in the pathogenesis of nephropathy and other diabetic complications (1-2).
1. Henderson NC, et al. Proc Natl Acad Sci 103(13):5060-5, 2006
2. Lacobini C, et al. J Am Soc Nephrol 14:S264-S270, 2003
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