|Application ||WB, IHC, IF|
|Calculated MW||26152 Da|
|Other Names||Galectin-3, Gal-3, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Galactose-specific lectin 3, Galactoside-binding protein, GALBP, IgE-binding protein, L-31, Laminin-binding protein, Lectin L-29, Mac-2 antigen, LGALS3, MAC2|
|Target/Specificity||A synthetic peptide corresponding to residues in human Galectin-3 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Galectin-3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.|
|Cellular Location||Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface|
|Tissue Location||A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages Expressed in fetal membranes.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Galectins are a family of beta-galactoside-binding animal lectins that are associated with diverse cellular events, including immune response. Glectin-3 has previously been identified in rat, mouse and human tissues and is evolutionarily highly conserved. It is an abundant cell-surface component of inflammatory macrophages and their major non-integrin laminin-binding protein. It is also mainly expressed in colonic epithelial cells. Galectin-3 is a cell surface receptor of the advanced glycosylation end products (AGE), which has involvement in the pathogenesis of nephropathy and other diabetic complications (1-2).
1. Henderson NC, et al. Proc Natl Acad Sci 103(13):5060-5,2006
2. Lacobini C, et al. J Am Soc Nephrol 14:S264-S270, 2003
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.