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Gamma Synuclein (SR) Antibody

Rabbit Monoclonal Antibody

  • WB - Gamma Synuclein (SR) Antibody AJ1313a
    A. Western blot analysis on fetal brain lysate using anti-gamma Synuclein RabMAb (Cat. #AJ1313a), dilution 1:2000.
  • IHC - Gamma Synuclein (SR) Antibody AJ1313a
    B. Immunohistochemical staining of paraffin-embedded human brain using anti-gamma Synuclein RabMAb (Cat. #AJ1313a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O76070
Reactivity Human, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1539Y
Calculated MW 13331 Da
Gene ID 6623
Other Names Gamma-synuclein, Breast cancer-specific gene 1 protein, Persyn, Synoretin, SR, SNCG, BCSG1, PERSYN, PRSN
Target/Specificity A synthetic peptide corresponding to residues on gamma Synuclein was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGamma Synuclein (SR) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
Cellular Location Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle
Tissue Location Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung
Research Areas
Citations (0)

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Synucleins are small, highly conserved proteins in vertebrates, especially abundant in neurons and typically enriched in presynaptic terminals. Synucleins (alpha, beta, gamma, and synoretin) are 14-kDa proteins that are highly expressed in brain but also found in numerous other tissues (1). It has been shown that gamma-synuclein is present in the perinuclear area and is localized to centrosomes in several types of human interphase cells and in bovine retinal pigment epithelium. In mitotic cells, gamma-synuclein staining is localized to the poles of the spindle. Further, overexpression of synoretin in retinoblastoma cells up-regulates MAPK and Elk-1. These results support the view that gamma-synuclein is a centrosome protein that may be involved in signal transduction pathways (2). gamma-Synuclein is implicated in some forms of cancer and ocular diseases. Data support the view that gamma-synuclein may change its intracellular localization and associate with subcellular structures in response to intracellular signaling or stress (3).


1. Pronin AN, et al. J Biol Chem 275(34):26515-22, 2000.
2. Surgucheva A, et al. Cell Motil Cytoskeleton 49(4):218-28, 2001.
3. Surgucheva A, et al. Cell Motil Cytoskeleton 63(8):447-58, 2006.

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Cat# AJ1313a
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