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Gata1 Antibody

Rabbit Monoclonal Antibody

  • WB - Gata1 Antibody AJ1316a
    A. Western blot analysis on K562 cell lysate using anti-Gata1 RabMAb (Cat. #AJ1316a), dilution 1:2000.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P15976
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP2819Y
Calculated MW 42751 Da
Gene ID 2623
Other Names Erythroid transcription factor, Eryf1, GATA-binding factor 1, GATA-1, GF-1, NF-E1 DNA-binding protein, GATA1, ERYF1, GF1
Target/Specificity A synthetic peptide corresponding to N-terminus of human Gata-1 was used as an immunogen.
Dilution WB~~1:1000~2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGata1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GATA1
Synonyms ERYF1, GF1
Function Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells.
Cellular Location Nucleus.
Tissue Location Erythrocytes..
Research Areas
Citations (0)

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Globin transcription factor 1 (GATA-1) is a transcription activator belonging to the GATA family of transcription factors with importance in cell growth. GATA-1 is a Cys2-Cys2 zinc finger DNA binding protein commonly found in erythroid red blood cells and megakaryotic platelet producing cells, and it is critical in the development process of both (1). It binds to the consensus sequence of [AT]GATA[AG] within regulatory regions of globin genes and genes in erythroid cells, leading to transcription of alpha spectrin structural protein necessary for the red blood cell's shape. In humans, GATA-1 can enhance the transcription rate up to 100 times (2). A mutation to the GATA-1 encoding gene has been implicated to X-linked dyserythropoietic anemia, thrombocytopenia, Down's syndrome in children, congenital transient myeloproliferative syndrome, and acute megakaryocytic leukemia (2, 3).


1. Osada H, et al., PNAS USA 92:9585-9, 1995.
2. Wong EY, et al., JBC 279:55024-33, 2004.
3. Wechsler J, et al., Nat Genet. 32: 148-52, 2002.

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Cat# AJ1316a
(40 western blots)
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