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Gelsolin Antibody

Rabbit Monoclonal Antibody

  • IHC - Gelsolin Antibody AJ1319a
    B. Immunohistochemical analysis of paraffin-embedded human tonsils using anti-Gelsolin RabMAb (Cat. #AJ1319a)
  • WB - Gelsolin Antibody AJ1319a
    A. Western blot analysis on NIH 3T3 cell lysate using anti-Gelsolin RabMAb (Cat. #AJ1319a), 1:5000 dilution.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P06396
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1940Y
Calculated MW 85698 Da
Gene ID 2934
Other Names Gelsolin, AGEL, Actin-depolymerizing factor, ADF, Brevin, GSN
Target/Specificity A synthetic peptide corresponding to residues in the C-terminal region of human Gelsolin was used as immunogen.
Dilution IHC~~1:100~250
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGelsolin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GSN
Function Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Cellular Location Isoform 2: Cytoplasm, cytoskeleton.
Tissue Location Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells
Research Areas
Citations (0)

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Gelsolin is a large and complex actin-binding protein that belongs to actin-severing gelsolin/villin super family. Gelsolin is a regulator of actin filament assembly and disassembly and consists of six homologous subdomains (S1-S6). When C-terminal tail (S6) is bound to calcium ion, it straightens and exposes actin binding sites located on S2s helices, leading to Gelsolin actin-serving activity (1). Gelsolin is inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2), where PIP2 will bind to S1, S2, and S3 sites. Gelsolin is involved in podosome formation and has been linked to inhibition of apoptosis by preventing release of cytochrome C (2).


1. Sun, H et al. J Biol Chem 274 (47): 33179
2. Koya, R, et al. J Biol Chem 275 (20): 15343-15349, 2000.

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Cat# AJ1319a
(40 western blots)
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