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Glucagon Antibody

Rabbit Monoclonal Antibody

  • WB - Glucagon Antibody AJ1321a
    Fig 1. Western blot analysis on (A) HepG2 and (B) human fetal liver (C) mouse kidney (D) mouse spleen lysates using anti-Glucagon RabMAb (Cat. #AJ1321a).
  • IHC - Glucagon Antibody AJ1321a
    Fig 2. Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Glucagon RabMAb (Cat. #AJ1321a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01275
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP3070
Calculated MW 20909 Da
Gene ID 2641
Other Names Glucagon, Glicentin, Glicentin-related polypeptide, GRPP, Oxyntomodulin, OXM, OXY, Glucagon, Glucagon-like peptide 1, GLP-1, Incretin hormone, Glucagon-like peptide 1(7-37), GLP-1(7-37), Glucagon-like peptide 1(7-36), GLP-1(7-36), Glucagon-like peptide 2, GLP-2, GCG
Target/Specificity A synthetic peptide corresponding to residues in human Glucagon was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGlucagon Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GCG
Function Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
Cellular Location Secreted.
Tissue Location Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP-1 and GLP-2 are also secreted in selected neurons in the brain
Research Areas
Citations (0)

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Glucagon is an important hormone involved in glucose metabolism and homeostasis (1). It regulates blood glucose by increasing gluconegenesis and decreasing glycolysis. It is synthesized and released by the alpha-cells of the islets of Langerhans in pancreas as the proglucagon and is preteolytically processed to yield the mature peptide (2). When the glucose level in the blood is low (hypoglycemia), Glucagon is released and binds to glucagon receptors on hepatocytes, causing the liver to release glucose through glycogenolysis. Upon the depletion of stored glycogen in the liver, Glucagon then stimulates liver to synthesize additional glucose by gluconeogenesis. It is a counter regulatory hormone of insulin, and plays an important role in initiating and maintaining hyperglycemic conditions in diabetes (3).


1. Quesada et al. Journal of Endocrinology. 199:5-19, 2008 2. Nadal et al. Journal of Physiology 517:85-93; 1999 3. Dunning et al. Diabetologia 48:1700-1713; 2005

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Cat# AJ1321a
(40 western blots)
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