|Calculated MW||20909 Da|
|Other Names||Glucagon, Glicentin, Glicentin-related polypeptide, GRPP, Oxyntomodulin, OXM, OXY, Glucagon, Glucagon-like peptide 1, GLP-1, Incretin hormone, Glucagon-like peptide 1(7-37), GLP-1(7-37), Glucagon-like peptide 1(7-36), GLP-1(7-36), Glucagon-like peptide 2, GLP-2, GCG|
|Target/Specificity||A synthetic peptide corresponding to residues in human Glucagon-like peptide 2 (GLP-2) was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Glucagon-like (GLP-2) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.|
|Tissue Location||Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP-1 and GLP-2 are also secreted in selected neurons in the brain|
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Provided below are standard protocols that you may find useful for product applications.
Glucagon is an important hormone involved in glucose metabolism and homeostasis (1). It plays an important role in initiating and maintaining hyperglycemic conditions in diabetes (2). It is synthesized and released by the alpha-cells of the islets of Langerhans in the pancreas as the proglucagon and is preteolytically processed to yield the mature peptide (3). Glucagon is cleaved into eight chains, one of which is Glucagon-like peptide 2 (GLP-2). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. GLP-2 plays a key role in nutrient homeostasis, enhancing nutrient assimilation (4).
1. Quesada et al. Journal of Endocrinology. 199:5-19, 2008 2. Nadal et al. Journal of Physiology 517:85-93; 1999 3. Dunning et al. Diabetologia 48:1700-1713; 2005 4. The UniProt Consortium. The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195 (2008)
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