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GluR2 Antibody

Rabbit Monoclonal Antibody

  • WB - GluR2 Antibody AJ1323a
    A. Western blot analysis on human brain celll lysate of using anti-GluR2 RabMAb (Cat. #AJ1323a), dilution 1:2000
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P42262
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP966Y
Calculated MW 98821 Da
Gene ID 2891
Other Names Glutamate receptor 2, GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2, GRIA2, GLUR2
Target/Specificity A synthetic peptide corresponding to a residue near N-term of human Glutamate receptor type 2 was used as immunogen.
Dilution WB~~1:2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGluR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRIA2
Synonyms GLUR2
Function Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Cellular Location Cell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression
Research Areas
Citations (0)

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Glutamate receptor type 2 (GluR2) is one of the four subunits of α-amino-5-hydroxy-3-methyl-4-isoxazole propionic acid (AMPA) receptor. AMPA receptor is a non-NMDA-type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS (1). AMPA receptors are composed of four types of subunits, designated as GluR1, GluR2, GluR3, and GluR4 (alternatively called GluRA-D), which combine to form tetramers (2). The complex comprising of GluR2 and GluR3 is one of the two predominant forms in the adult hippocampus. All four GluRs interact with specific cytoplasmic protein through their C-terminal tails. Although in contrast to GluR1 and GluR4, GluR3 and GluR2 have a short C-terminal tail (3).


1. Pellegrini DE, et al. Proc Natl Acad Sci 88:4157-4161 2001.
2. Boehm J, et al. Biochem Soc Trans 33:1334-1336. 2005.
3. Dingledine R, et al. Pharm Review 51:7-62. 1999.

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Cat# AJ1323a
(40 western blots)
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