|Application ||WB, IF|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||83786 Da|
|Other Names||Glycogen [starch] synthase, muscle, GYS1, GYS|
|Target/Specificity||A synthetic peptide corresponding to residues in the C-terminus of the human glycogen synthase was used as immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Glycogen-Synthase Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan.|
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Provided below are standard protocols that you may find useful for product applications.
Glycogen synthase is an enzyme of the transferase class that catalyses the reaction of UDP-glucose and (1,4-α-D-glucosyl)n to yield UDP and (1,4-α-D-glucosyl)n+1 (1-2). This tetrameric enzyme is the rate-limiting step for glycogen synthesis (3). Glycogen concentrations are regulated by the complementary activities of glycogen phosphorylase and glycogen synthase. Glycogen synthase activity is regulated by phosphorylation of serine residues and by insulin stimulation (4). Glycogen synthase is known to have two forms; the unphosphorylated and most active form, synthase-a, and the phosphorylated glucose-6-phosphate-dependent form, synthase-b.
1. Browner, M. F.; Nakano, K.; Bang, A. G.; Fletterick, R. J. : Proc. Nat. Acad. Sci. 86: 1443-1447, 1989.
2. Skurat, A., and Roach, P. J. (1996) in Diabetes Mellitus pp. 213-222.
3. Hardy, T. A., and Roach, P. J. (1993) J. Biol. Chem. 268, 23799-23805
4. Skurat, A. V., Wang, Y. & Roach, P. J. (1994) J. Biol. Chem. 269, 25534
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