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Glycogen-Synthase Antibody Phospho (pS641)

Rabbit Monoclonal Antibody

     
  • WB - Glycogen-Synthase Antibody Phospho (pS641) AJ1326c
    A. Western blot analysis on mouse muscle lysates using anti-Phospho-Glycogen Synthase (pS641) RabMAb (Cat. #AJ1326c), 1:10,000 dilution. Cells were either (A) untreated (B) treated with AP.
  • IHC - Glycogen-Synthase Antibody Phospho (pS641) AJ1326c
    B. Immunohistochemical analysis of human liver using anti-Phospho-Glycogen Synthase (pS641) RabMAb (Cat. #AJ1326c).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P13807
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EP852Y
Calculated MW 83786 Da
Gene ID 2997
Other Names Glycogen [starch] synthase, muscle, GYS1, GYS
Target/Specificity A synthetic phospho-peptide corresponding to residues surrounding Ser641 of human Glycogen Synthase was used as immunogen. The antibody only detects Glycogen Synthase phosphorylated on Serine 641.
Dilution WB~~1:500~1000
IHC~~1:100~250
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGlycogen-Synthase Antibody Phospho (pS641) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GYS1
Synonyms GYS
Function Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan.
Research Areas
Citations (0)

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Background

Glycogen synthase is an enzyme of the transferase class that catalyzes the reaction of UDP-glucose and (1,4-α-D-glucosyl)n to yield UDP and (1,4-α-D-glucosyl)n+1 (1-2). This tetrameric enzyme is the rate-limiting step for glycogen synthesis (3). Glycogen concentrations are regulated by the complementary activities of glycogen phosphorylase and glycogen synthase. Glycogen synthase activity is regulated by phosphorylation of serine residues and by insulin stimulation (4). Glycogen synthase is known to have two forms; the unphosphorylated and most active form, synthase-a, and the phosphorylated glucose-6-phosphate-dependent form, synthase-b.

References

1. Browner MF, et al. Proc Nat Acad Sci 86:1443-1447, 1989.
2. Skurat A, et al. Diabetes Mellitus, pp 213-222. 1996.
3. Hardy TA, et al. J Biol Chem 268:23799-23805, 1993.
4. Skurat AV, et al. J Biol Chem 269:25534

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Discontinued
Cat# AJ1326c
Size:
(40 western blots)
Alternative Products:

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