|Application ||WB, IHC|
|Calculated MW||83786 Da|
|Other Names||Glycogen [starch] synthase, muscle, GYS1, GYS|
|Target/Specificity||A synthetic phospho-peptide corresponding to residues surrounding Ser641 of human Glycogen Synthase was used as immunogen. The antibody only detects Glycogen Synthase phosphorylated on Serine 641.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Glycogen-Synthase Antibody Phospho (pS641) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan.|
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Provided below are standard protocols that you may find useful for product applications.
Glycogen synthase is an enzyme of the transferase class that catalyzes the reaction of UDP-glucose and (1,4-α-D-glucosyl)n to yield UDP and (1,4-α-D-glucosyl)n+1 (1-2). This tetrameric enzyme is the rate-limiting step for glycogen synthesis (3). Glycogen concentrations are regulated by the complementary activities of glycogen phosphorylase and glycogen synthase. Glycogen synthase activity is regulated by phosphorylation of serine residues and by insulin stimulation (4). Glycogen synthase is known to have two forms; the unphosphorylated and most active form, synthase-a, and the phosphorylated glucose-6-phosphate-dependent form, synthase-b.
1. Browner MF, et al. Proc Nat Acad Sci 86:1443-1447, 1989.
2. Skurat A, et al. Diabetes Mellitus, pp 213-222. 1996.
3. Hardy TA, et al. J Biol Chem 268:23799-23805, 1993.
4. Skurat AV, et al. J Biol Chem 269:25534
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