|Application ||WB, IHC|
|Calculated MW||113086 Da|
|Other Names||Golgin subfamily A member 2, 130 kDa cis-Golgi matrix protein, GM130, GM130 autoantigen, Golgin-95, GOLGA2|
|Target/Specificity||A synthetic peptide corresponding to residues near the N-term of human Golgi Matrix Protein (GM130) was used as a immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GM130 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Golgi Matrix Protein (GM130) is peripheral cytoplamic protein that is bound to the Golgi membranes. It has been implicated as a maintainer of cis-Golgi structure (1). During mitosis, it regulates the disassembly and reassembly of the Golgi complex. It is also linked to docking and fusion of coatomer (COP I) coated vesicles to the Golgi membrane (2). The COOH-terminal domain of GM130 is highly homologous to Golgi human auto-antigen, golgin-95. GM130 interacts specifically and GTP-dependent manner with Rab1b protein, a regulator of anterograde traffic between ER and Golgi membranes (3). GM130 is also activator of YSK1, an essential player in cell migration.
1. Nakamura N, et al. J Cell Biol 131:1715-1726, 1995
2. Warren G, Annual Rev Biochem 62:323-348, 1993
3. Weide T, et al. EMBO Rep 2:336-341, 2001
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