|Reactivity||Human, Mouse, Rat|
|Calculated MW||37331 Da|
|Other Names||Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2, G protein subunit beta-2, Transducin beta chain 2, GNB2|
|Target/Specificity||A peptide corresponding to residues near C-term of human GNB2 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GNB2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.|
|Cellular Location||Cytoplasm, perinuclear region|
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Provided below are standard protocols that you may find useful for product applications.
Guanine nucleotide binding protein beta-2 (GNB2) is a G-protein subunit belonging to WD repeat G protein beta family. GNB2 functions as a modulator or transducer for trans-membrane signaling pathway systems. G-protein is composed of alpha, beta, and gamma subunits, where beta and gamma subunits are required for GTPase activity and G-protein effector interaction (1). Specifically, GNB2 interacts with the glucocorticoid and migrates into the nucleus to suppress GR-induced trans-activation of the glucocortoid-responsive genes (2). GNB2 has been identified as a binding partner to Ataxin 10, an important target in SCA10 disorder, and also a partner in regulating NTE, a protein known to cause delayed neuropathy with degeneration of nerve axon (3, 4).
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