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Heme Oxygenase-1 (HO-1) Antibody

Rabbit Monoclonal Antibody

  • WB - Heme Oxygenase-1 (HO-1) Antibody AJ1338a
    A. Western blot analysis on fetal liver lysate using anti-HO-1 RabMAb (Cat. #AJ1338a), dilution 1:2000
  • IHC - Heme Oxygenase-1 (HO-1) Antibody AJ1338a
    B. Immunohistochemical staining of paraffin-embedded human liver using anti-HO-1 RabMAb (Cat. #AJ1338a).
  • IF - Heme Oxygenase-1 (HO-1) Antibody AJ1338a
    C. Immunofluorescent staining of HeLa cells using anti-HO-1 RabMAb (Cat. #AJ1338a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P09601
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EP1391Y
Calculated MW 32819 Da
Gene ID 3162
Other Names Heme oxygenase 1, HO-1, HMOX1, HO, HO1
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus of human HO-1 was used as an immunogen.
Dilution WB~~1:5000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHeme Oxygenase-1 (HO-1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HMOX1
Synonyms HO, HO1
Function Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
Cellular Location Microsome. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side
Tissue Location Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level)
Research Areas
Citations (0)

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Stressed mammalian cells up-regulate heme oxygenase 1 (HO-1), which catabolizes heme to biliverdin, carbon monoxide, and free iron. Results provide genetic evidence that up-regulation of HO-1 serves as an adaptive mechanism to protect cells from oxidative damage during stress (1). When cells are injured they release their contents, resulting in a local accumulation of free heme proteins and heme. HO-1 plays a crucial role in the inflammatory process during wound healing (2). TNFalpha accelerates inflammatory responses by down-regulating HO-1 expression in human monocytes. TNF antagonists may block this TNF-dependent suppression of HO-1 expression, resulting in an amelioration of inflammation (3).


1. Poss KD, et al. Proc Natl Acad Sci USA 94(20):10925-30, 1997.
2. Wagener FA, et al. Blood 102(2):521-8, 2003.
3. Kirino Y, et al. Arthritis Rheum 56(2):464-475, 2007.

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Cat# AJ1338a
(40 western blots)
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