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HER3 (ErbB3) Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - HER3 (ErbB3) Antibody (C-term) AJ1341a
    A. Western blot analysis on MCF-7 cell lysate using anti-ErbB3 (C-term) RabMAb (Cat. #AJ1341a), 1:500 dilution.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21860
Reactivity Human, Rat
Host Rabbit
Clonality Monoclonal
Clone Names E186
Calculated MW 148098 Da
Gene ID 2065
Other Names Receptor tyrosine-protein kinase erbB-3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, ERBB3, HER3
Target/Specificity A synthetic peptide corresponding to C-terminal residues of human c-erbB3 was used as immunogen.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHER3 (ErbB3) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ERBB3
Synonyms HER3
Function Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Epithelial tissues and brain.
Research Areas
Citations (0)

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HER3 / ErbB3 is a member of the ErbB/EGF receptor protein tyrosine kinase family (1,2). Tyrosine phosphorylation of ErbB3 depends on its association with other ErbB tyrosine kinases (3). Phosphorylation sites in the carboxy-terminal tail mediate downstream signaling pathways. While ErbB3 is highly expressed in many cancer cells (4), ErbB3 may work together with other Erb members in tumorogenesis and proliferation (5).


1. Katoh, M., et al. c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase. Biochem Biophys Res Commun. 192: 1189
2. Kraus, M.H., et al. Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci U S A. 86: 9193
3. Guy, P.M., et al. Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. Proc. Natl. Acad. Sci. USA 91: 8132
4. Sithanandam, G., et al. Cell cycle activation in lung adenocarcinoma cells by the ErbB3/phosphatidylinositol 3-kinase/Akt pathway. Carcinogenesis 24: 1581
5. Alimandi, M., et al. Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. Oncogene 10: 1813

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Cat# AJ1341a
(40 western blots)
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